Modification of Na Channels by Synthetic Dihydrobatrachotoxinin A - 20 « - Benzoate
نویسندگان
چکیده
Sodium channels in nodal membrane modified by a synthetic analog of batrachotoxin, 7,8-dihydrobatrachotoxinin A-20a-benzoate, were studied under voltage clamp conditions. The voltage dependence of channel activation was shifted by 70—80 mV towards more negative potentials. Selectivity sequence determined from peak current reversal potenial was as follows: Na:NH 4 :K = 1:0.46:0.23. Our data suggest that 7,8-dihydrobatrachotoxinin A-20a-benzoate has qualitatively similar effects on the properties of sodium channels as does natural batrachotoxin.
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